1. INTRODUCTION When delving into the realms of codon optimality, we must first take a step back to observe our definitions and origins. At the most fundamental level, our genome is constructed from four basic building blocks, the nucleotides adenine (A), cytosine (C), guanine (G) and thymine (T). When a transcript (utilising a uridine (U) […]
Biological Impact of Codon Optimality in Translation Read More »
November 12th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Ferguson et al. (2023) present a simplified method to improve ribosome footprint enrichment in comparison to ribosomal RNA and decreased sequencing bias. Millius
Translatomics for Ribo-seq, uORF control and RNA stability Read More »
November 5th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Ngoennet, S. et al. investigated how altering the expression of Elongation factor G impacts various aspects of cellular function, particularly translation processes and
Translatomics for stress tolerance, microproteins and ISR Read More »
October 29th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Volegova et al. investigate the specific role of the helix-loop-helix motif in the eIF3A subunit, and its impact on selective translation. Later, we
Translatomics for eIF3A, frameshifting and RNA repeats Read More »
October 22nd Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Joiret et al. investigate the electric field of the catalytic centre of ribosomes using a geometrical model. Choudhary et al. explore azole resistance
Translatomics for translation kinetics, C albicans and pgRNA Read More »
October 15th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Sako et al. find that miRNAs play a pivotal role in preventing protein misfolding, Papaspyropoulos et al. explore the variations in translational deregulation
Translatomics for miRNA, senescence and tumors Read More »
October 8th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Froberg et al. (2023) propose nanoRibo-seq, an optimised protocol which makes it possible to examine translational regulation within only a few thousand cells.
Translatomics for uORF, mRNA interactomes and Mycoplasma Read More »
September 24th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Müller et al. investigate the mechanisms of translational quality control within the context of stop codon readthrough, while later on in the piece,
Translatomics for quality control, queuosine and readthrough Read More »
September 17th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Cuevas et al. (2023) discuss their tool, BamQuery, designed to analyse MHC-I-associated peptides with lengths between 8 to 11 amino acids. Bowazolo &
Translatomics for tumor antigens, light-dark cycles and TOR Read More »
September 10th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Albers, S. et al developed strategies to overcome limitations in restoring full-length protein production in genetic disorders caused by nonsense mutations. A study
Translatomics for Suppressor tRNA, ribosome stalling and m6A Read More »
