September 3rd Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Zhulyn et al. (2023) show a distinct characteristic of the injury response necessary for limb regeneration in the axolotl. Munro et al. (2023) […]
Translatomics for mTOR, RNA integrity and SNPs Read More »
Nonsense Suppression Therapy Nonsense mutations, single nucleotide changes which replaces a codon that encodes for an amino acid with a stop codon resulting in truncated protein products, give rise to approximately 11% of inherited diseases in humans. Nonsense suppression therapeutics may act as viable treatments for such diseases by allowing ribosomes to read through premature
Insights on Nonsense Suppression Therapy with Translatomics Read More »
Small Molecules Targeting Translation In the present day, the vast majority of pharmaceutical therapeutics target specific proteins or enzymatic reactions. However, due to conformational challenges, in addition to other issues, a wide number of such proteins remain “undruggable” with current technologies. One solution put forward to address these issues has been to target these proteins
Targeting Translation with Small Molecules Read More »
uORF detection Upstream open reading frames (uORFs) are sequences with start and stop codons found upstream of the main protein coding region in an area known as the 5’ untranslated region (UTR). uORFs can vary by number per transcript, by length and by their position in relation to the 5’ cap and main start codon.
Detecting uORFs with Translatomics Read More »
August 20th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Campbell et al. look at the role of NMD on DUX4 expression in facioscapulohumeral muscular dystrophy (FSHD), Chen, Yu & Wong look at
Translatomics featuring compounds regulating translation Read More »
August 20th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Campbell et al. look at the role of NMD on DUX4 expression in facioscapulohumeral muscular dystrophy (FSHD), Chen, Yu & Wong look at
Translatomics for NMD, m6A and tuberculosis Read More »
August 13th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Buscà et al. uncover a novel mechanism governing start codon selection, while Yang et al. investigate the role of the N4-acetylcytidine modification in
Translatomics for start codon, gastric cancer and elongation Read More »
August 6th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Song et al. present a comprehensive functional model of m6A regulation mediated by m6A reader proteins in plants. Kejiou et al. look at identified
Translatomics for m6A, ribosome stalling and suppressor tRNA Read More »
July 30th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Qanmber et al. look at the role of translation in cotton fibre development, Meng et al. look at RMC-6272 – a selective mTORC1
Translatomics for cotton fibre, mTORC1 and pep-tRNA Read More »
July 23rd Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, we see a fascinating novel finding, in that Zhang, F et al. report the first multicellular eukaryotic example of an anticodon nuclease, activated
Translatomics for anticodon nuclease, m6A and oogenesis Read More »
