Author name: Oscar Ting

Translation Elongation Rates: Insights and Implications

Exploring Translation Kinetics with Advanced Tools, Translatomics in Action

Translation Elongation Rates In order to maintain a healthy proteome, the ribosome must not only generate sequences of peptides in sufficient quantities to serve their biological purpose but must also ensure that these polymers correctly fold into their native structures to yield fully functional proteins. Somewhat counter-intuitively, these mutually beneficial processes of protein synthesis and […]

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Ribosome Pausing: Mechanisms and Implications in Translation

Exploring Translation Kinetics with Advanced Tools, Translatomics in Action

Ribosome Pausing The process of translation is characterized by variation in the local decoding rates of specific mRNA codons. There are known cases where pausing or stalling is used for regulating protein synthesis. These are frequently found in the translated ORFs in 5’UTRs whereby the paused ribosome  alters the progression of ribosomes to the CDS.  Ribosome

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Optimizing Biotherapeutic Protein Yields with Translatomics

Translatomics for insights into Therapeutics, Translatomics in Action

Optimising Biotherapeutic Protein Yields The primary determinants for successful recombinant protein expression are high expression levels of the recombinant genes, translation efficacy and post-translational modifications. Transcriptomic and proteomic tools have helped in our understanding of the molecular basis of protein expression. However, while RNA-Seq provides insight into transcription it fails to take into consideration that

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Targeting Translation with Small Molecules

Translatomics for insights into Therapeutics

Small Molecules Targeting Translation In the present day, the vast majority of pharmaceutical therapeutics target specific proteins or enzymatic reactions. However, due to conformational challenges, in addition to other issues, a wide number of such proteins remain “undruggable” with current technologies. One solution put forward to address these issues has been to target these proteins

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Insights on Plant Abiotic Stress Tolerance via Translatomics

3 Comments / Translatomics in Action, Translatomics Tools in Plant Biology Research

Abiotic Stress Tolerance Translation is a tightly controlled mechanism in response to abiotic stress tolerance in plants, partly due to how energetically expensive this process is. Under hostile conditions, plants significantly downregulate growth, choosing to conserve resources until more favourable conditions return. It also plays a key role in rapidly producing protective proteins, increasing the

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Translatomics in Biofuel Production: Insights and Benefits

Translatomics - Applications in the field of Microbiology, Translatomics in Action

Biofuels and Commodities With the advent of genetic engineering, a revolution occurred within the sector of biofuel and commodity production. Suddenly, microbes were being utilised as scaffolding structures upon which to produce commercially valuable chemicals, for use in a wide range of industries. However, while gene expression analysis tools, such as RNA-Seq, were able to

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Complete Differential Gene Expression via Translatomics

Cutting-Edge Gene Expression Analysis Tools, Translatomics in Action

Complete Differential Gene Expression Identifying what proteins are being expressed at a cellular level in response to a drug or as a consequence (or cause) of a pathological state is fundamental to our understanding of disease phenotypes and a logical starting point for the design of therapeutics for targeting them. However, researchers have often limited

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Understanding Viral-Host Interactions with Translatomics

Innovative Biomedical Research with Translatomics Tools, Translatomics in Action

Viral-Host Interaction Translation within the context of viral-host interaction is a crucially important factor in determining the propagation of the invading pathogen. Due to their lack of cellular organelles, it is a requirement upon most viruses to hijack host machinery, in particular the translational apparatus such as the ribosomes. This feature of viral infection means

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Unraveling Cancer Aetiology with Translatomics

Innovative Biomedical Research with Translatomics Tools, Translatomics in Action

Cancer Aetiology Translation is a key process in a wide range of cancers, being significantly altered to drive its initiation and progression. Practically all oncogenic signalling pathways (including RAS–MAPK, PI3K–AKT–mTOR, MYC and WNT–ß-catenin) are implicated in translational reprogramming and many oncogenes (including KRAS, PTEN, APC, and EGFR) also regulate signalling pathways targeting translation.  It is

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Translatomics and Cardiometabolic Health: Key Insights

Innovative Biomedical Research with Translatomics Tools, Translatomics in Action

Cardiometabolic Health Cardiometabolic diseases, significant causal factors in heart attacks and strokes, are the leading cause of death worldwide. With the growing rates of cardiometabolic disorders in the Western world, a greater understanding of the mechanisms behind such disorders are increasingly required. While this has been an extensively researched area in recent times, much of

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