Author name: Oscar Ting

Neurological Disease Insights Through Translatomics

Innovative Biomedical Research with Translatomics Tools, Translatomics in Action

Translatomics in Action: Neurological Disease The dysregulation of translation in the central nervous system (CNS) has been linked to multiple neurodegenerative diseases, making translatomics a particularly important set of tools for learning and understanding more about neurological disease. Among the diseases in which translation has been implicated are amyotrophic lateral sclerosis (ALS) and frontotemporal lobar […]

Neurological Disease Insights Through Translatomics Read More »

RAN-Translation in Neurological Disease

Innovative Biomedical Research with Translatomics Tools, Translatomics in Action

RAN-Translation in Neurological Disease A range of human neurological disorders occur due to nucleotide repeat expansions which can cause disease by protein gain-of-function, protein loss-of-function, or RNA gain-of-function. The FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene is responsible for making FMRP; a protein found in the brain, ovaries and testes among many other tissues. FMRP

RAN-Translation in Neurological Disease Read More »

Predicting Alternative Proteoforms with Translatomics

Insights on Alternative Proteoforms with Translatomics Tools, Translatomics in Action

Alternative Proteoform Prediction Multiple translation initiation sites (TISs) may allow for alternative proteoforms to arise from the translation of just a single mRNA. RNA-Seq is limited in that it cannot be utilized to predict alternative proteoforms, and the standard proteomics approaches alone may prove insufficient. In this regard, Ribosome profiling (Ribo-Seq) could be advantageous when

Predicting Alternative Proteoforms with Translatomics Read More »

Insights into Translation Initiation Through Translatomics

Translatomics in Action

Translation Initiation ​Translation is initiated when the small ribosomal subunit, which scans from the 5’ end of the mRNA, recognises a start codon. Identifying sites of translation initiation is desirable for uncovering alternatively translated reading frames. When ribosomes initiate at noncanonical start codons of open reading frames (ORF), this creates a more diversified proteome without

Insights into Translation Initiation Through Translatomics Read More »

Micropeptide Prediction via Translatomics

Translatomics in Action

Micropeptide Prediction Micropeptides are peptides that are generally considered to be less than 150 amino acids in length. The identification of these short peptides has been limited by their size, abundance, and the current standard parameters for defining protein-coding regions. They are noteworthy in that the evolutionary conservation of the ORFs protein coding potential tends

Micropeptide Prediction via Translatomics Read More »

Translatomics for RNA decay, proteome and lipid metabolism

Weekly digest of translatomics developments every sunday

June 11th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers Duviau et al. explore the RNA degradosome in E.coli, Hadjeras et al. looks at the small proteome in the plant symbiont Sinorhizobium meliloti and Ma et al. look at lipid metabolism in Acer

Translatomics for RNA decay, proteome and lipid metabolism Read More »

Translatomics for posttranscriptual control, lipids and RBPs

Weekly digest of translatomics developments every sunday

June 4th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Sidhaye et al. (2023) describe how posttranscriptional factors affect protein abundance and gene expression during human corticogenesis. Ma et al. (2023) used ribosome footprint profiling in conjunction

Translatomics for posttranscriptual control, lipids and RBPs Read More »

Translatomics for RRP15, CDK13 and IDRs

Weekly digest of translatomics developments every sunday

May 28th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Dong et al. (2023) report that RRP15 inhibition could disrupt β-catenin signalling and inhibit CRC proliferation and metastasis. Wu et al. (2023) investigated the role of CDK13

Translatomics for RRP15, CDK13 and IDRs Read More »

Translatomics for glutamine, tRNA and osteosarcoma

Weekly digest of translatomics developments every sunday

May 21st Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Tsukamoto et al. investigate the regulatory mechanisms governing glutamine homeostasis under conditions of amino acid starvation, while Shiraishi et al. delve into the specifics of translation in

Translatomics for glutamine, tRNA and osteosarcoma Read More »

Translatomics for ribosomal proteins, spliceosome and maize

Weekly digest of translatomics developments every sunday

May 14th Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Milenkovic et al. (2023) report that incorporation of tissue-specific ribosomal protein alters ribosome localisation rather than its translational output. Jung et al. (2023) investigate the role and

Translatomics for ribosomal proteins, spliceosome and maize Read More »

Scroll to Top