April 28th, 2024 Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Hansel Fröse, A.F. et al. look into dynamic alternative polyadenylation start sites which might alter the availability of miRNA target sites in 3′ […]
Translatomics for alternative APA, tRNA and regulatory RBPs Read More »
April 21st, 2024 Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Dos Santos et al. delve into the regulation of the ribosome quality control complex, Shields et al. shed light on bacterial rRNA methylation,
Translatomics for RQC, antibiotic resistance and m6A Read More »
April 14th, 2024 Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Andjus et al. (2024) use ribosome profiling to confirm ribosome binding to Xrn1-sensitive lncRNAs and identify actively translated 5’-proximal small ORFs in yeast.
Translatomics for lncRNA, Huntington’s Disease and NMD Read More »
Translatomics, the comprehensive study of an organism’s translation processes, offers a profound understanding of how plants synthesize proteins and regulate gene expression in response to internal and environmental cues. This blog post delves into several recent studies that utilize translatomic approaches to uncover the dynamic landscape of protein synthesis in plants. These investigations reveal not
Exploring Plant Biology Through Translatomics Read More »
April 7th, 2024 Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, Ramachandra et al. uncover the importance of BCL6 in governing transcriptional regulation of skeletal muscle differentiation and translation, while Shi et al. delve
Translatomics for proteostasis, tRNA and frameshifting Read More »
March 31st, 2024 Recent Publications Harnessing the Power of Translatomics. Every week we provide a digest of a small number of recent interesting papers in the field of translatomics. In this week’s Sunday papers, we delve into the intricacies of genetic decoding in plants and humans. Discoveries include the role of lncRNAs in stem cell differentiation, the
Translatomics for lncRNAs, readthrough and iron stress Read More »
Gene expression is the process by which genetic information is used to make the proteins which carry out the biological functions essential to all life. Interrogation of this process at a global level facilitates early-stage drug discovery and allows signatures of disease susceptibility to be elucidated. This type of analysis is typically carried out at the level of transcription
Enhance RNA expression results Read More »
Numerous diseases, ranging from cancer to neurodegenerative disorders, exhibit dysregulated translation as a central feature of their pathogenesis. Translation, the process by which mRNA is translated into functional proteins, is finely regulated to maintain cellular homeostasis. However, aberrant translation can lead to the production of harmful proteins, disruption of cellular processes, and ultimately disease onset and progression. Traditional approaches such
Complete gene expression profiling Read More »
Dysregulated translation lies at the heart of numerous pathological conditions, including cancer, neurodegenerative disorders, and infectious diseases. Unravelling the specific genes, pathways, and regulatory mechanisms driving aberrant translation offers promising avenues for therapeutic intervention. Identifying whether lead compounds for disease targets impact global translational signatures is a useful first step in understanding their pharmacological effects and potential therapeutic efficacy. Polysome
Measure translational activity with Polysome Profiling Read More »
Ribosome stalling (also known as ribosome pausing) occurs physiologically across most of the transcriptome and is known to facilitate co-translational folding of the nascent peptide chain. Prolonged stalling, however, can also lead to ribosome collisions arising due to transcript mutations or defective nascent peptides, ultimately resulting in both the transcript and the nascent polypeptide being targeted for degradation. Global
Investigate ribosome collisons with Disome-Seq Read More »
